Fig 5.tif (121.53 kB)
Modeling the effect of Treg on effector T cell growth.
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posted on 2017-12-01, 18:25 authored by Vishal Koparde, Badar Abdul Razzaq, Tara Suntum, Roy Sabo, Allison Scalora, Myrna Serrano, Max Jameson-Lee, Charles Hall, David Kobulnicky, Nihar Sheth, Juliana Feltz, Daniel Contaifer Jr., Dayanjan Wijesinghe, Jason Reed, Catherine Roberts, Rehan Qayyum, Gregory Buck, Michael Neale, Amir ToorModeling the effect of Treg on effector T cell growth, red curve, r reduced at 21st iteration from -1 to -0.25; T cell population drops but then recovers slowly. In the blue curve r reduced at 25th iteration from -1 to +0.25 with direction reversal (from–to +), signifying anti-inflammatory cytokine effect supersedes pro-inflammatory cytokine effect.
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DRPMRDT cell count differencesURDalloreactive peptide bindingSNPWESSCTcell transplantation Quantitative relationshipcytotoxic T cell clonal vector matrixDynamical system modelingdonor T cell responsealloreactive donor T cell responsesorgan-specific alloreactive T cell clonal growthHLA binding affinityorgan-specific T cell countsalloreactive donor cytotoxic T cell responseGVHDICtissue expression
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