Mitochondrial stress test: Oxygen consumption rates in HepG2 cells cultured in ELO water- and or control (regular) water-based media at normal (5.5 mM)- or high (25 mM)-glucose concentrations.
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posted on 2021-07-14, 17:26 authored by Joan Khoo, Christoph E. Hagemeyer, Darren C. Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong TeoSignificant differences between OCRs linked to basal respiration, ATP production and proton leak are indicated by * = p < 0.01.
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Results ELO waterdiabetes 12 yearsdrink 1.5 litresELO waterglucose concentrations5.5 mM glucoseincreases oxidative stress25 mM glucoseage 53 yearsadjuvant therapytype 2 diabetesoxygen tension pO 2ad libitum ELOmitochondrial functionrandomized 150 adultsmitochondrial proton leakmitochondrial massConclusions ELO waterHepG 2 cellsflow cytometry analysisrandomized placebo-controlled trial...Mitochondrial stress testingHyperbaric oxygenation therapyblood oxygen levelsmitochondrial dysfunction
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