Mid-diaphyseal femur morphology.

Mid-diaphyseal femur morphology is presented as a function of time after treatment for RTx and Sham groups. (A) Diaphyseal cortical cross-sectional area; (B) diaphyseal cortical thickness; (C) diaphyseal total cross-sectional area; (D) diaphyseal endosteal (marrow) cross-sectional area; (E) diaphyseal minimum moment of inertia (I_min); and (F) maximum moment of inertia (I_max). By 8–12 weeks RTx femurs lose cortical mass through resorption at the endosteal surface. Data are presented as mean ± standard deviation, n = 15 femurs/group/end point. Asterisks (*) denote p < 0.05 for Sham vs. RTx at each end point via an unpaired Student’s t-test.