S1 Fig.tif (339.68 kB)
The relationship of drd1a gene to Shati/Nat8L expression.
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posted on 2017-03-20, 18:04 authored by Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi NittaThe Figure indicates that the relationship between Shati/Nat8L expression and METH effect on brain slice experiments. **p<0.01 vs. aCSF. (Newman–Keuls post hoc test). (B) Dopamine D1 or D2 receptor antagonist (D1: SCH23390 10uM, D2: sulpiride 10uM) was pretreated before METH (1mM) stimulation for qPCR of Shati/Nat8L mRNA. **p<0.01 and ***p<0.001 vs., aCSF## p<0.01 vs.METH. (Newman–Keuls post hoc test). (C) PC12 cells transfected with drd1a or drd2 were taken for qPCR 48 after the transfection * p<0.05 vs pcDNA (Newman–Keuls post hoc test). Error bars represent the S.E. M
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mouse NAc slicesMETH activates CREB bindingPC 12 cellsmouse brain slicesmouse NAcdopamine receptor signalsgroup II mGluRsSCHmouse nucleus accumbensdopamine D 2 receptor antagonist sulpiridemRNAexpressionCREB activitydopamine D 1 receptorMETH-induced CREB pathwaydopamine D 1 receptor agonist SKF 38393Shatimouse NAc attenuated METH-induced hyperlocomotion
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