Loss of heterozygosity events are more common in tumor suppressor genes.
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posted on 2018-11-08, 18:47 authored by David M. Vossen, Caroline V. M. Verhagen, Reidar Grénman, Roelof J. C. Kluin, Marcel Verheij, Michiel W. M. van den Brekel, Lodewyk F. A. Wessels, Conchita Vens(A) The percentage of HNSCC samples with LOH per TSG (dark red) and OG (dark blue). HNSCC TSG and oncogenes (OG) are as reported by Leemans et al. Light colors represent the percentage of samples without LOH (wt). Fraction of samples with LOH are indicated by numbers and dark colors. (B) Boxplot representation of the percentage of HNSCC tumor samples with LOH in any TSGs or OGs as shown in Fig 3A. TSGs are enriched for LOH events (p<0.005).
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crosslink repair statusDNA repair endpoint association BackgroundMMC sensitivitytumor suppressor gene identification studiesSNP allele frequenciesHRsubset harbors DNA repair defectsgene function associationtumor cellsKEGG FA pathwayDNA crosslink repair deficiencycancer genome studiestumor suppressor genesDNA sequence variant selection proceduresDNA repair functionDNA repair defectsvariant allele fractionHNSCCvariant selection strategies29 patient-derived head
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