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Ionophoric antibiotics narasin inhibits mucus secretion.

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posted on 2018-02-22, 18:34 authored by Hyo Jung Sim, Sang-Hyun Kim, Kyung-Jae Myung, Taejoon Kwon, Hyun-Shik Lee, Tae Joo Park

A. The mucus granules were stained with WGA-Alexa 488 to visualize retained mucus granules. Narasin treated goblet cells (last panel) displayed severe retention of mucus granules. B. Ionophoric antibiotics, Monensin and Nigericin, inhibit mucus secretion similar to narasin. C. Narasin treatment increased intracellular levels of glycosylated protein.

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    Several muco-active agentsalternative model systemXenopus laevis embryosvivo model systemvivo model systemsnovel screening techniqueairway goblet cellslung epithelial cell linemucus secretionDNAmuco-active agentsCurrent muco-active reagents control mucus secretionCOPDmuco-active reagents

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