Intracellular uptake of nanoparticles.

Intracellular uptake of MRN-HSA-NPs, AT1-HSA-MRN-NPs and Scr-HSA-MRN-NPs in H9c2 cells (a) Normal cells (non-hypoxic, non-hypertrophic), (b) Hypoxic cells and (c) Hypertrophic cells. The nanoparticle concentration was 0.5 mg/mL. The graph shows a representative result of mean ± SD (n = 3). ****p<0.0001 was considered highly significant and ***p<0.001, **p<0.01 were considered significant based on Tukey’s posthoc analysis.