Infarct volume analysis, cerebral hemisphere swelling and representative images of coronal brain slices as assessed 24-hours after permanent MCAO.
Treatments were administered intravenously (saline vehicle, or R18 and R18D at 300 nmol/kg) 30 min after MCAO. A: Infarct volume measurements. †Denotes animal that died several hours before the 24-hour post-MCAO study end-point, but was still included in the final infarct volume analysis. Unfilled circles, triangles and squares represent infarct volumes obtained from outlier animals excluded from the study. B: Percentage hemisphere swelling for vehicle and the R18 and R18D treatment groups. C: Representative images of TTC stained coronal brain slices from vehicle, R18 and R18D treatment groups. Values are mean ± SD; n = 9–10. *p < 0.05 when compared to vehicle.