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Induction of E-cadherin expression and inhibition of HDACs by hit compounds in PANC-1 cells.
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posted on 2016-10-20, 17:50 authored by Kishore Polireddy, Ruochen Dong, Peter R. McDonald, Tao Wang, Brendan Luke, Ping Chen, Melinda Broward, Anuradha Roy, Qi ChenA. Western blot analysis of E-cadherin in PANC-1 cells that were exposed to two different concentrations of cluster#1 and 2 compounds. Concentrations for compound 150 were 0.5 and 1 μM. B. Western blot analysis of E-cadherin in PANC-1 cells that were exposed to 25 μM of cluster#2 compounds for 24 hrs. C. Western blot analysis in PANC-1 and BxPC-3 cells for E-cadherin, N-Cadherin, and Snail. Cells were treated with BSI (25 μM) for 24hrs. D. Western blot analysis in PANC-1 and BxPC-3 cells for H2A-Lys5, H3-Lys9, and H4-Lys8. Cells that were exposed to BSI (25 μM) for 24hrs.
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pancreatic cancer cell migrationtumor spheres formationPancreatic Cancer Cell Invasionstem-like cancer cellsCSC inhibitorsinhibitioncompoundEMTTargeting Epithelial-Mesenchymal Transitiondrug screening assaysHTScancer cell epithelial-to-mesenchymal transitionE-cadherin expressionBSIhistone 4 acetylationsphere formation assaycancer cell populationTumor Spheres Formation Background Pancreatic cancerPANCpancreatic cancer cell line
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