Immunohistochemistry for Alzheimer’s disease.
figure
posted on 2022-07-29, 17:27 authored by Johanna Alexandra Tejada Moreno, Andrés Villegas Lanau, Lucia Madrigal Zapata, Ana Yulied Baena Pineda, Juan Velez Hernandez, Omer Campo Nieto, Alejandro Soto Ospina, Pedronel Araque Marín, Lavanya Rishishwar, Emily T. Norris, Aroon T. Chande, I. King Jordan, Gabriel Bedoya BerrioFig 1A and 1B. Immunohistochemistry for beta amyloid in the occipital cortex region. A. Occipital 2.5X, B. Occipital 5X. Multiple neuritic plaques are observed (red arrows), as well as amylodean angiopathy (blue arrows), which affects the meningeal vessels. Fig 1C and 1D. Immunohistochemistry for tau protein in the hippocampus region at the level of the lateral geniculate body. C. Hippocampus CGL 5X, D. Hippocampus CGL 10X. Multiple tangles and neurofibrillary threads are observed(black arrows), that affect the different portions of the hippocampus.
History
Usage metrics
Categories
Keywords
synaptic functioning mechanismssequenced two affectedone unaffected memberfavor hydrophobic interactionsamyloid -&# 946alzheimer &# 8217potential risk variantsmthfd1l variants showsidentifying genetic variantsstructural 3d modelslocal structural changesspanning three generationsmthfdl1 possibly contributemthfd1l genes segregatinghighly penetrant mutationsthree genescandidate variantsstructural modelmay contributewithout mutationsused wholesporadic formsprotein functionoligogenic inheritancelipid metabolismimmune systemfamilial formsexome sequencingeleven memberscould explaincould affectcommon causealso built97 members152 million
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC