Immune escape mutations have high accessibility scores.

CDFs of AAS are shown for mutations that were shown experimentally by Cao et al. [7] to reduce binding to neutralizing antibodies (gold). For reference, we show AAS distributions of surface residues (blue) and all residues (black) of spike, as well as all RBD surface residues (brown). Score distributions were calculated (A) without glycans and (B) with glycans. The KS statistic is the maximum vertical gap between the respective CDFs and is indicated by a red arrow in (B).