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IV-KAPhE can identify instances where literature-derived kinase-phosphosite assignments are probably assigned in error to commonly studied isozyme, instead of a lesser-studied one.

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posted on 13.05.2022, 17:43 by Brandon M. Invergo

a) IV-KAPhE assignments of ribosomal protein S6 kinase alpha isozymes for all sites annotated in PhosphoSitePlus as being phosphorylated by at least one of the isozymes. Red colors indicate assignments predicted as likely by IV-KAPhE. Highlighted sites, discussed in the text, are examples that IV-KAPhE predicts are more likely to be phosphorylated by a different isozyme than the one annotated. b) IV-KAPhE assignments of calcium/calmodulin-dependent protein kinase type II subunits to annotated sites, as described in (a).