Fig 3.tif (145.88 kB)
Host versus pathogen control of LRRK2 expression levels.
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posted on 2016-02-04, 21:45 authored by Vinicius M. Fava, Jérémy Manry, Aurélie Cobat, Marianna Orlova, Nguyen Van Thuc, Nguyen Ngoc Ba, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin SchurrLRRK2 expression levels for 53 unrelated subjects are indicated on the y-axis and stratified according to rs2404580 genotypes on the x-axis. The left panel represents baseline expression while the right panel indicates gene expression levels following stimulation with M. leprae antigen.
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Missense LRRK 2 VariantLRRK 2 missense variant M 2397TLRRK 2 locusM 2397T variantT 1R LRRK 2 involvementT 1R SNPsLRRK 2LRRK 2 gene encodesT 1R susceptibility.MethodologyAn association scanLRRK 2 protein turnoverT 1R associationLRRK 2 gene transcriptional levels.Principal FindingsAMycobacterium leprae antigen.SignificanceThe results supportT 1R familiesLRRK 2 geneLRRK 2 variantsT 1RLRRK 2 availability18 T 1R variantsT 1R susceptibility gene
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