Histograms illustrating the expression of 3 genes encoding proteins known to be aberrant in different NDDs.
ADAM10 and SCNA mRNAs significantly increased with E–treatment, whereas PSEN1 mRNA significantly decreased with E-treatment in the chow-fed monkeys. The effect of E observed in the chow-fed monkeys was lost in the WSD-fed monkeys. In addition, transcript abundance was decreased by an order of magnitude for ADAM10 and PSEN1 in the WSD- compared to chow-fed monkeys. * Bonferroni posthoc p<0.001.