Heatmap generated from the 581 DMPs obtained in the HbSC group compared to the control group.
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posted on 2022-09-21, 17:42 authored by Gislene Pereira Gil, Galina Ananina, Mariana Maschietto, Sheila Coelho Soares Lima, Sueli Matilde da Silva Costa, Leticia de Carvalho Baptista, Mirta Tomie Ito, Fernando Ferreira Costa, Maria Laura Costa, Mônica Barbosa de MeloThe rows represent each DMP and the columns each patient in the HbSC group and controls (CTL). The colors represent the methylation levels; the more red the more methylated and the more blue the less methylated. From these 581 DMPs, a total of 68 DMPs were in common with those obtained in the HbSS group.
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sickle cell diseasehypermethylated cpgs sitesgestational age newbornsgene expression changesfgr ), stillbirthfetal growth restrictiondifferentially methylated regionsdata strongly suggestincreased hypermethylation statusgene expression analysisdna methylation profilechanges possibly contributearray data validationabnormal placental developmentdiv >< p86 %) groupsmethylation validationpossibly leadingincreased riskepigenetic analysis89 %)placental insufficiencyplacental abnormalitieshbsc groupsuncomplicated controlstaken togetherspock1 ptgfr obstetrical complicationsmolecular mechanismshowever littlehbaa genotypeshbaa ).gpr56 could impactcontrol groupanalyses threealso showedadcy4
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