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Download fileH/D exchange of PRC1-DD.
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posted on 05.08.2022, 20:04 authored by Fei Tan, Jin Xu(a) Bar graph showing the protection factor of each amide proton in PRC1-DD, schematic representations of PRC1-DD structure were also provided on top of the figure. (b) Bar graph showing the unfolding free energy (ΔGex) of each residue. (c) Experimentally determined free energy of unfolding (ΔGex) mapped to PRC1-DD solution structure. The ΔGex ranges are: fast exchangers (purple) ΔGex ≥ 30000; medium exchangers (white) ΔGex = 15000–30000; slow exchangers (cyan) ΔGex ≤ 15000. Figures were drawn using CHIMERA.
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hydrophobic core packingdeuterium exchange experiments>- helix h2proteins called microtubulecycle dependent proteinsn terminal residuesalso generated mutantsdiv >< pconformation prc1 adoptedhigh resolution threeprc1 </ presolution solution structureassociated proteinsn terminusalso differentalpha </prc1 ’prc1 callswhole proteinused hydrogenthermal stabilityspindle midbodysolution structuressolution structureresults suggestplacing hurdlesphysiological significancenmr spectroscopyincomplete sidechainshuman mapfunction relationshipsdistinguishing memberdimerization domaindimensional structurebind microtubules
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