H3K4me2 epigenetic signature predicts tissue and cell specificity of TSS.

A. Changes of H3K4me2 occupancy around TSS+/-1000bp during mouse retina development as ratio of normalized number of reads at PN15/PN1 for rod and common TSS of retina genes with multiple TSS. At the bottom: average number of H3K4me2 reads accumulation for each group of TSS at PN1 and PN15. **p = 0.0011. B. Changes of H3K4me2 occupancy around TSS+/-1000bp during mouse erythropoiesis as ratio of normalized number of reads between late and early erythroblast for rod and common TSS of retina genes with multiple TSS. At the bottom: average number of H3K4me2 reads accumulation for both groups of TSS at early and late stages. C. Changes of H3K4me2 occupancy around TSS+/-1000bp during mouse brain development as ratio of normalized number of reads for whole brain and neuronal progenitor for rod and common TSS of retina genes with multiple TSS. At the bottom: average number of H3K4me2 reads accumulation for both groups of TSS at early and late stages. D. Changes of H3K4me2 occupancy around TSS+/-1000bp during mouse retina development for TSS of control groups of genes (non-rod, cell-cycle and synapse).