Genes that interact with HIV-1 under selection.
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posted on 2018-05-25, 17:32 authored by Erik Corona, Liuyang Wang, Dennis Ko, Chirag J. PatelThe genes are sorted from left to right by highest to lowest mean selection across the 19 populations exhibiting a p-value < 0.1 for selection associated with HIV-1. The cumulative effect of a moderate selection signal allows for the detection of positive selection in these genes. The top 3 genes are KARS, NGLY1, and POLR2K (leftmost on the axis) are known inhibit HIV-1 replication.
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Yersenia pestisBacillus anthracishuman-pathogen interactomedengue virusmeasles virusarms raceHuman genespathogen interaction databasehost-pathogen protein interaction networksGWASpathogen-interacting genesSystematic detectiondisease-causing agentsHuman Genome Diversity PanelFrancisella tularensisRubella viruspestis showsyncytial virusHIV susceptibility variantsBiaka Pygmy populations9 pathogen species show evidenceimmunodeficiency viruspathogen exposurelentivirus pandemicshaplotype scoredisease susceptibility
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