Gene therapy general concept.

With the current analysis, a cluster dynamic (A), is modulated from its initial condition in three distinct ways: complete inhibition of cluster expression (B), freezing cluster expression at the initial (baseline) condition (C), and fixed overexpression of the cluster expression (D). The modification in cluster expression alters the cell or ECM kinetics, leading a new trajectory for hyperplastic growth of the wall (E)-(G). Dashed line represents the dynamic in absence of therapy and the solid line, the dynamic post-therapy.