Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH - Fig 5
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posted on 2018-05-30, 17:38 authored by Daniela Carmen Oniciu, Taishi Hashiguchi, Yuichiro Shibazaki, Charles L. BisgaierA) NAS Score; B) Fibrosis area.
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MIPNASH Backgroundhigh-caloric dietcell-signaling genesCCRSTAMdownregulated hepatic mRNA markerslipid modulationinflammationgemcabeneUnited StatesGemcabene interventionliver-related deathTIMPhepatocyte ballooningACCanti-inflammatory efficacylipid metabolismliver failureliver diseaseNFhepatocellular carcinomafibrosis progressionsupport predictionnon-clinical findingsADHnonclinical modelsMMPGemcabene downregulatesNAFLD ActivityMethods Gemcabeneliver fibrosisResults Gemcabenehepatic histologicalTNFmRNA markersMCP
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