GTTs and ITTs in Ocn–/–mice.

(A) GTT by glucose (2 g/kg body weight) injection. Glucose levels in male mice (wt: n = 9, Ocn–/–: n = 12) at 5 months of age fed a normal diet. (B and C) GTT by glucose (1 g/kg body weight) injection. Glucose (B) and insulin (C) levels in male mice at 9 months of age fed a normal diet. wt: n = 9, Ocn–/–: n = 7. (D and E) GTT by glucose (2 g/kg body weight) injection. Glucose (D) and insulin (E) levels in male mice (wt: n = 8, Ocn–/–: n = 12) at 6 months of age fed a high-fat diet for 1 month. (F) ITT. Glucose levels in male mice (wt: n = 20, Ocn–/–: n = 12) at 4 months of age fed a normal diet. (G) ITT. Glucose levels in male mice (wt: n = 7, Ocn–/–: n = 12) at 8 months of age fed a high-fat diet for 3 months.