Functional groups in ClueGO overview.

The pie charts present functional groups for analyzed genes, based on GO, KEGG, Reactome and WikiPathways annotation by ClueGO Cytoscape plug-in, then clustered into STRING action enriched (a), combined score (b), database score (c), and textmining (d) categories. The name of the group is given by the group leading term (the most significant term in the group). The group sections correlate with the number of the terms included in the group. Network structure of functional groups is calculated on kappa Score, which shows the relationships between the terms based on their overlapping genes.