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Fig 6 -

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posted on 2023-05-25, 17:45 authored by Gaurav Bajpai, Samuel Safran

(a) Snapshot of simulation of block copolymer model in the presence of nuclear boundary (lamin) attractions for a chain volume fraction of ϕ = 0.3. (b) Overlapping between Chr2 and Chr3 is shown. Lamin beads are shown by green points. Chr2 and Chr3 regions in 3D are represented by the line, and overlapping regions of Chr2 and Chr3 are shown by red and blue points. (c) The contact map for case (a). (d) The contact map and chromosome mixing index are calculated for the simulation shown in (a) by omitting the heterochromatin regions. Note that in the contact maps, vertical and horizontal colored lines are added to distinguish the chains, which correspond to the colors of the chromosomes. (e) Contact map and chromosome mixing index are calculated from the Hi-C experiments data of Drosophila genome [27]. Note that the contact map calculated from our simulation (in (d)) is noisy but similar to the experimental contact map (in (e)). Both maps show that the euchromatic parts of chromosomes 2L and 2R are separated with little mixing, as well as chromosomes 3L and 3R, as evidenced by the five red squares on the diagonal of (d) and (e). This is interesting because it was achieved using only one interaction parameter in the simulation (attraction strengths between all euchromatic beads were the same in our simulation).