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posted on 2022-03-16, 17:26 authored by Tamara Kreiss, Tyler Eck, Brittany Hart, Sreedhar Tummalapalli, David Rotella, John SiekierkaBiological functions affected by treatment of B. malayi males with 100 nM of MSU-TSR-6-44 (A and B) or MSU-TSR-6-38 (C and D). Gene classification was conducted with the Panther Classification System Gene Analysis tool, using the B. malayi Genome as a reference. (Mi H et. al. 2018; Mi H et. al. 2019).
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structural comparison searchsevere side effectsmedicinal chemistry effortsdiv >< pclose structural similarityloa loa histone demethylase inhibitorsbrugia malayi potent killing activityadult filarial parasitesmalayi adult parasitesminimal activityhistone methylationb parasites treatedfilarial drugstoxic liabilitiesscreening programresults indicatepotential antiparasitic nematodesparasitic eyewormparasite responsiblenovel seriesnovel approachnew classmight indicatemicrofilariae killingmajor causelimited efficacylife threateninglarval formslargely usedkilling microfilariaeinsect vectorsindividuals throughoutdrug actioncontraindicative duechronic morbidityaffects millions
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