pone.0232230.g004.tif (350.25 kB)
Expression of IL-33, ST2L, cytokines and chemokines in orthotopic tumors.
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posted on 2020-04-27, 17:30 authored by Keizo Takenaga, Miho Akimoto, Nobuko Koshikawa, Hiroki Nagase(A) RT-qPCR analysis of Il33 and ST2L in Panc02-shCont and Panc02-sh#5 tumors (n = 3). (B) Gene expression profiling of cytokines and chemokines between Panc02-shCont and Panc02-sh#5 tumors were performed using a PCR array. (C) RT-qPCR analysis of various chemokine (C-X-C motif) ligands and Cxcr2 in Panc02-shCont and Panc02-sh#5 cells (n = 3) and tumors (n = 7–9). (D) RT-qPCR analysis of Cxcl13 in Panc02-shCont (n = 7) and Panc02-sh#5 tumors (n = 9). The data are shown as the mean ± SD. *P<0.05. **P<0.001. ns, not significant.
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modulates IL -33-STmouse pancreatic cancer cell linesmouse pancreatic cancer Panc 02 cellsreceptor ST 2Lpancreatic cancer cellsCxcl 3 expressioncolon cancer cellsCXCL 3mRNA expression levelsCXCL 3-CXCR axisPCRpancreatic cancersST 2-expressing mouse pancreatic cancer Panc 02 cellstumor microenvironmentConclusions Cancer cell-derived sST 2Methods ST 2cancer cell-derived interleukin -33 decoy receptor sST 2IL -33 decoy receptor sST 2orthotopic tumor growthsST 2 secretionMPOtumor growthshRNA-resistant sST 2 mRNAsST 2sST 2 expressionELISAIL -33 knockout miceSBC 57BL micemurine pancreatic cancer model Background Proinflammatory interleukin -33tumor tissuesIL -33-ST
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