Fig 2.tif (1.1 MB)
Enrichment analysis of miRNA-seq data.
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posted on 2017-09-08, 18:05 authored by David J. Schultz, Penn Muluhngwi, Negin Alizadeh-Rad, Madelyn A. Green, Eric C. Rouchka, Sabine J. Waigel, Carolyn M. KlingeDifferentially expressed genes were identified in pairwise comparisons: MCF-7 AnAc vs. MDA-MB-231 AnAc using the tuxedo suite of programs including cufflink-cuffdiff2. The Venn diagrams show the number of common and differentially expressed genes significantly downregulated (A) and upregulated (B). Pathway analysis was performed using GeneGo Pathways Software (MetaCoreTM). The pathways identified for each comparison are listed in the order provided by MetaCoreTM analysis.
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SINbreast cancer cells MicroRNAsMYCTNBCgenome-wide microRNA transcriptomeMetaCore Gene Ontologycell linesVIM mRNA transcript expressionERmiR -20bWhole genome expression69 AnAc-responsive miRNAsMCF -7 cellsAnAc-treated MDA-MB -231 cellsbreast cancerAnAc-treated MCF -7 cellsmiRNA arm preferencemiR -20b target EFNB 2 transcript levelsPPARMCF -7 estrogen receptor αB cell receptorICGenome-wide miRNA responseMDA-MB -231 cells
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