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Effect of post-symptomatic therapeutic administration of anti-VP6 VHH on RVA shedding in feces.

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posted on 2016-09-07, 17:42 authored by Lucía Maffey, Celina G. Vega, Samuel Miño, Lorena Garaicoechea, Viviana Parreño

Mean titer of virus shed (determined by ELISA) detected daily in pooled feces from mice receiving pre-symptomatic and post-symptomatic treatment comprising 200 μg of 2KD1 and the untreated control group. The arrow shows inoculation time (PID 0). Post-symptomatic administration of 2KD1 (200 μg) significantly reduced overall fecal shedding with respect to the untreated control group when AUC comparison was performed (ANOVA, p = 0.002). The thin horizontal line indicates the duration of VHH passive treatment. PID: Post Inoculation Day.