Fig 8.tif (503.48 kB)
Effect of CD44 on hyaluronic acid and osteopontin levels upon combined HSM/CS exposure.
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posted on 2016-03-21, 05:35 authored by Smitha Kumar, Ellen Lanckacker, Mieke Dentener, Ken Bracke, Sharen Provoost, Katrien De Grove, Guy Brusselle, Emiel Wouters, Tania Maes, Guy JoosHA (A) and OPN (B) levels in BALF of WT and CD44 KO mice that were exposed for 3 weeks to PBS/air, PBS/CS, HDM/air or HDM/CS. *p<0.05, **p<0.01, ***p<0.005; n = 8–10 mice/group.
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airway inflammation.MethodsWild typemediastinal lymph node cultures.ResultsIn WT micegoblet cell metaplasiamurine modelmediastinal lymph nodesPBSCD 44peribronchial eosinophiliaAllergic Airway Inflammationbronchoalveolar lavage fluidOPNmediatorhouse dust miteTh 17 cytokine productionBALFattenuated Th 2 cytokine productionCStransmembrane glycoprotein CD 44HDMHATh 2 cytokine productionCD 44 KO miceexposure
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