Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate) - Fig 2

Effect of efavirenz (10 μM) on transcellular transport of 2 nM[³H]-MPP⁺ (A) and 10 nM [³H]-lamivudine (C) from the basal to the apical compartment, and intracellular accumulation of [³H]-MPP+ (B) and [3H]-lamivudine (D) in monolayers of MDCK-OCT1, MDCK-OCT2, MDCK-MATE1, MDCK-OCT1-MATE1, MDCK-OCT2-MATE1, and control MDCK-Co cells over 2 hours. Data are shown as means ± SD of at least three independent experiments performed in duplicate. Results were analysed using the multiple t-test **P≤ 0.01 ***P ≤ 0.001.