Distribution of microtubules in lamellipodia in cells expressing IQGAP1 mutants.

A) Representative color combine images of IQGAP1 full length (FL) or IQGAP1 mutants (S1441E S1441D, S1441A S1443A, delta-CHD, delta-GRD and delta-CT) in green and microtubules in blue. B) Average number of microtubule ends within 2.1μm of the lamellipodium edge. The average edge length of lamellipodia was 80μm. ***p<0.001 Tukey’s post hoc test compared to FL. n = 11–15 cells for each bar. Bars = mean +/- s.e.m.