Fig 4.tif (2.42 MB)
Distribution of microtubules in lamellipodia in cells expressing IQGAP1 mutants.
figure
posted on 2017-12-14, 18:42 authored by Michael Reimer, Elisabeth Denby, Silviya P. Zustiak, Joseph M. SchoberA) Representative color combine images of IQGAP1 full length (FL) or IQGAP1 mutants (S1441E S1441D, S1441A S1443A, delta-CHD, delta-GRD and delta-CT) in green and microtubules in blue. B) Average number of microtubule ends within 2.1μm of the lamellipodium edge. The average edge length of lamellipodia was 80μm. ***p<0.001 Tukey’s post hoc test compared to FL. n = 11–15 cells for each bar. Bars = mean +/- s.e.m.
History
Usage metrics
Keywords
IQGAP 1 mutantsWWmelanoma cellsIQGAP 1 functionIQGAP 1 localizationGRDcontrol IQGAP 1 activityactin cytoskeleton dynamicsCHDtissue culture polystyreneIQGAP 1B 16F mouse melanoma cellsmelanoma cells IQGAP 1CTtissue culture plasticcalponin homology domainmembrane rufflingC-terminal domain-dependent localization1441A1441Elamellipodium protrusionRas GAP-related domain
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC