pmed.1002781.g002.tif (1.06 MB)
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study - Fig 2
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posted on 2019-04-16, 17:26 authored by Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson, David Sterling, Stanley Kimbung Mbandi, Kirsten M. Wall, Michelle Fisher, Sara Suliman, Smitha Shankar, Willem A. Hanekom, Nebojsa Janjic, Mark Hatherill, Stefan H. E. Kaufmann, Jayne Sutherland, Gerhard Walzl, Mary Ann De Groote, Urs Ochsner, Daniel E. Zak, Thomas J. ScribaReceiver operator characteristic AUC analysis of the TRM5 signature for (A) ACS training set and (B) test set progressor and nonprogressor plasma samples, stratified by the time interval of each prospectively collected sample before the date of TB disease diagnosis. ACS, Adolescent Cohort Study; AUC, area under the curve; TB, tuberculosis; TRM5, TB Risk Model 5.
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generalizable signature performanceACS trainingTB diagnosisTB diseasecohort study Background3 PR signature5- protein signatureGambian validation cohortfindings Proteomic TB risk signaturesPrognostic performance3- protein signature1 yearprognostic proteomic signature6 monthsnonsputum blood testAUCmultiplexed proteomic assayproteomic TB risk signaturesTRM 5 signatureAdolescent Cohort Studyprognostic proteomic signaturesTB Risk Model 5month 18. Amongst2 yearsTarget Product Profile
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