Differences between solution and crystal structures.

(a)–(b) The hydrophobic-core composition of (a) solution and (b) crystal structures with residues having significant differences being tagged. (c) Relative solvent-accessible surface area (SASA) as a function of residue number (x-axis); each residue SASA value is represented as a black dot; green continuous line belongs to the SASA values of the crystal structure, while dotted red line represents solution-structure SASA values.