pgen.1007530.g006.tif (303.57 kB)
Difference between observed and expected number of significant pathways arising from Gene Ontology Biological Process categories.
figure
posted on 2019-03-15, 17:39 authored by Ryan Sun, Shirley Hui, Gary D. Bader, Xihong Lin, Peter KraftFor a given phenotype, expected number is equal to the percentage of all tested pathways belonging to a category multiplied by the total number of significant pathways. The difference between observed and expected counts is expressed as a percentage of the expected number. A value greater than 0 indicates there are more significant pathways in a category than expected. A value less than 0 indicates there are less significant pathways than expected. A number of familiar themes are present, including the high number of significant height pathways related to growth and the high number of significant schizophrenia pathways related to the immune system.