pbio.3001505.g008.tif (743.47 kB)
Download file

Delamination defects in gata1 mutants leads to increased cell proliferation.

Download (743.47 kB)
figure
posted on 14.01.2022, 18:40 by Renee Wei-Yan Chow, Hajime Fukui, Wei Xuan Chan, Kok Soon Justin Tan, Stéphane Roth, Anne-Laure Duchemin, Nadia Messaddeq, Hiroyuki Nakajima, Fei Liu, Nathalie Faggianelli-Conrozier, Andrey S. Klymchenko, Yap Choon Hwai, Naoki Mochizuki, Julien Vermot

(A) Number of cells in different valve regions at 98 hpf. p-Values based on unpaired t test. (B) Representative images of 98 hpf gata1 control and mutant valves incubated with EdU from 74 to 98 hpf. Scale bars: 20 μm. (C) Graph showing number of EdU positive cells in 98 hpf gata1 controls and mutant valves. p-Values are based on unpaired t tests. (D) Graph showing fraction valve cells that stained positive for EdU in 98 hpf gata1 controls and mutant valves. p-Values are based on Welch t test. (E) Graph showing fraction of abluminal and luminal cells in 98 hpf gata1 controls and mutant valves that stained positive for EdU. p-Values are based on 2-way ANOVA. AVC, atrioventricular canal; hpf, hours postfertilization; VIC, valve interstitial cell.

History