Fig 3.tif (567.34 kB)
Degree of heteroresistance at major loci.
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posted on 2017-05-18, 17:32 authored by Darwin J. Operario, Alexander F. Koeppel, Stephen D. Turner, Yongde Bao, Suporn Pholwat, Sayera Banu, Suporn Foongladda, Stellah Mpagama, Jean Gratz, Oleg Ogarkov, Svetlana Zhadova, Scott K. Heysell, Eric R. HouptLoci whereby at least 5% of isolates had some degree of mutation are shown, as well as known rpoB and eis mutations. The y-axis shows the degree of heteroresistance, with each ‘X’ symbol representing a single isolate. Horizontal lines are median values. Loci are shown on the x axis. In rare instances whereby an isolate had more than one mutation at the same locus, the mutation with the highest degree of heteroresistance is shown.
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genotypic-phenotypic PZA susceptibility correlationscodonmultidrug-resistant tuberculosis Amplicon-basedNGSresistance-associated mutationGeneration Sequencing3519 nucleotideslevel pncA heteroresistanceMDR strainsgene regionsDSTTBMycobacterium tuberculosis drug susceptibility testingmultidrug-resistant Mgeneration sequencing11 resistance-associated gene regionsHeteroresistant loci
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