DENV1B shows higher replication efficiency in IFNAR1^-/- mice and cells.

(A-B) The viral RNA replication (A) and virus production (B) of DENV1 B and E in in MEF cells from WT mice. (C-D) The viral RNA replication (C) and virus production (D) of DENV1 B and E in MEF cells from IFNAR1^-/- mice. (E-H) The viral loads in whole blood cells (WBC) (E-F) and spleens (G-H) from DENV1 B and DENV1 E infected IFNAR1^-/- mice. (The viral loads were determined by qRT-PCR analysis of viral genes (E and G) or plaque titration of viral particles (F and H) as described above.) Results were shown as Mean±SEM, * p<0.05, **p<0.01, ***p<0.001 t- test. The data shown are representative of at least 3 independent experiments.