pgen.1008586.g007.tif (703.29 kB)

Crystallite size in the BAp c-axis and Young’s modulus in femurs of female wild-type and Ocn^–/–mice at 9 months of age.

figure

posted on 2020-05-28, 17:25 authored by Takeshi Moriishi, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Tomoka Hasegawa, Toshihiro Miyazaki, Wenguang Liu, Ryo Fukuyama, Yuying Wang, Hisato Komori, Xin Qin, Norio Amizuka, Toshihisa Komori

(A) The crystallite size in the BAp c-axis in the longitudinal and vertical directions at position 5. (B) Young’s modulus along the bone longitudinal axis at position 5 in Fig 6A as measured by nanoindentation. **: P<0.01. X symbols in box plots show outliers. (C) Single regression analysis of Young’s modulus to BMD and each degree of the preferential alignment of collagen fibers and the BAp c-axis in the bone longitudinal direction at position 5. wt: blue dots, Ocn^–/–: red dots. wt: n = 5, Ocn^–/–: n = 6. (D) Schematic presentation of orientations of collagen fibrils and BAp c-axis. In wild-type mice, the orientations of collagen fibrils and BAp c-axis are parallel to the bone longitudinal axis. In Ocn^–/–mice, the orientation of collagen fibrils is parallel to the bone longitudinal axis, whereas that of BAp c-axis is severely disrupted from the longitudinal axis. The disruption of the BAp c-axis orientation reduces Young’s modulus in the longitudinal axis.