Fig 5.tif (611.64 kB)
Cordycepin mediates the regulation of MKK7 by GADD45B via NF-κB suppression.
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posted on 2017-10-18, 17:50 authored by In-Hu Hwang, Seung Yoon Oh, Hyun-Jin Jang, Eunbi Jo, Jong Cheon Joo, Kyung-Bok Lee, Hwa-Seung Yoo, Mi Young Lee, Soo Jung Park, Ik-Soon Jang(A) Effect of GADD45B on MKK7 expression in cordycepin-treated TK-10 cells. (B) Effect of MKK7 on JNK expression in cordycepin-treated TK-10 cells. (C) Effect of TNF-α-induced NF-κB on c-FLIPL expression. (D) Effect of c-FLIPL on JNK expression in cordycepin-treated TK-10 cells. The data represent the mean ± SE from three independent experiments. **p < 0.01 and *** p < 0.001.
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c-FLIP L inhibitionNF -κB c-FLIP Lc-FLIP L overexpressionc-FLIP LMKK 7-JNKc-FLIP L expression Cellular FLICETK -10 cell apoptosisCordycepin downregulated GADD 45Bcancer cell apoptosiscordycepin-mediated JNK activationJNK inhibitor SP 600125cordycepin-treated TK -10 cellsupregulated MKK 7siRNA-mediated knockdownNF -κBc-FLIP L expressionTNFTK -10 cells
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