Concentration-response curve (CRC) plot.
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posted on 2024-07-03, 17:31 authored by Douglas A. Dawson, Terry W. SchultzThe plotted curves are for 3-methyl-2-butanone (3M2B) alone, hydroxypropyl methacrylate alone (HPM), the 3M2B-HPM mixture (MX) and the predicted concentration addition (CA) and independent action (IA) models. Note that the MX toxicity is consistent with that predicted for IA but more toxic than predicted for CA. Each CRC is given in 3M2B-equivalent concentrations (the upper X-axis). The lower X-axis depicts the CRC for actual HPM alone concentrations.
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variance inflation factorcontaining binary mixturesallovibrio fischeri 32 binary combinationsthree effect levelsmodel predictions usingcoincident &# 8221electrophiles div >< ppolar narcotic 3greater toxic hazardpotentially reactive electrophiledevelop predicted crcspredicted ia ecpredicted ca ecmixture toxicity modelschemical b ).potentially reducemx ).model systemseffect level&# 8220ca ecsuspected mechanismsham mxsseven groupingsresponse curvesmx crcsmixture toxicitymixture testingindependent actionevaluate toxicitydevelop equationschemical bca ratherbioluminescence inhibitionalways chemical
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