Circulating NETs components are higher in T2R patients, which decrease after thalidomide treatment.
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posted on 2019-09-10, 17:22 authored by Camila Oliveira da Silva, André Alves Dias, José Augusto da Costa Nery, Alice de Miranda Machado, Helen Ferreira, Thais Fernanda Rodrigues, João Pedro Sousa Santos, Natalia Rocha Nadaes, Euzenir Nunes Sarno, Elvira Maria Saraiva, Verônica Schmitz, Maria Cristina Vidal PessolaniPatient serum samples were obtained; and the levels of the DNA-histone (A, B) and DNA-MPO (C, D) complexes were quantified by ELISA. DNA-MPO complex levels are expressed as percentages values above the blank. (B, D) Follow-up of the complexes serum levels during thalidomide treatment. Outliers were removed from analysis. Box plots show median, interquartile range, sample minimum, and maximum. Each dot represents a donor. **P<0.01 (Mann Whitney test). (E) Spearman’s correlation between DNA-histone and DNA-MPO complexes per patient (n = 36, r = 0.5247, P = 0.001).
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type 2 reactionsTLR 9T 2R DNA recognitionT 2R neutrophilsvivo NETosis parametersT 2R patientsNETs formationleprosy type 2 reactionsT 2R skin lesionsNETs productionT 2R pathogenesisT 2R symptomsmycobacterial TLR 9 ligandT 2RNeutrophil extracellular trapsprognostic reactional markersneutrophil DNA extracellular trapsleprae whole-cell sonicatenovel alternative therapiesTLR 9 expressionT 2R lesions
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