pgen.1010599.g003.tif (153.94 kB)
Download fileChronic kidney disease (CKD) region on chr28 (chr28:30.8–31.4 Mb).
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posted on 2023-01-24, 18:35 authored by Frode Lingaas, Katarina Tengvall, Johan Høgset Jansen, Lena Pelander, Maria H. Hurst, Theo Meuwissen, Åsa Karlsson, Jennifer R. S. Meadows, Elisabeth Sundström, Stein Istre Thoresen, Ellen Frøysadal Arnet, Ole Albert Guttersrud, Marcin Kierczak, Marjo K. Hytönen, Hannes Lohi, Åke Hedhammar, Kerstin Lindblad-Toh, Chao WangThree candidate markers (green dots) from Bayesian analysis were found in this CKD region with the highest effect of 0.002. One selection signal was found nearby the candidate markers. Most of the imputed variants were located in the intergenic region between the WDR11 and FGFR2 genes in the same TAD.
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wide association analysiskidney cell linesfollowing comparative analysisanova test showedtotal four variantsthree intronic variantshuman regulatory datahuman kidney developmentckd phenotypic variation21 ckd regionsdiv >< pchronic kidney disease117 canine cases2 risk allelescanine ckd206 variantsprotective allelescases carriedhuman populationckd regiontop markerssignificantly higherreln </one variantmay enlightenmagi2 </intergenic regiongalnt18 </fgfr2 </also commonaffects 10
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