## Changes in EPSC parameters have little effect on the ISI distribution.

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We investigated how changes to the EPSC parameters affect the ISI distribution in the HH model when the spike rate is kept constant at 9 spikes/s. (**A)** Increasing the EPSC magnitude (Δ_{epsc}) slightly increases the number of short ISIs, shifting the distribution to the left, with a small decrease in the height of the mode. Plotted distributions are for EPSP magnitudes of ~ 1, 2, 3, and 4 mV (darkest to lightest). The changes in EPSPs that result from the changes in *k*_{epsc} are plotted on the right. EPSC rates (*R*_{epsc} = 2920, 1294, 774 and 526 Hz respectively) were adjusted to achieve a firing rate of 9 spikes/s. **(B)** Increasing the EPSC time-constant (τ_{epsc}) very slightly increases the number of short ISIs, shifting the distribution to the left, with a small decrease in the height of the mode. Plotted distributions are for τ_{epsc} = 1.1, 2.2, 3.3, and 4.4 ms (yellow to dark red). The changes in EPSPs that result from the changes in τ_{epsc} are plotted on the right. EPSC rates (*R*_{epsc} = 2685, 1220, 774, and 567 Hz respectively) were adjusted to achieve a firing rate of 9 spikes/s.