Fig 1.tif (335.41 kB)
CLK1 inhibitors described in the literature.
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posted on 2018-05-03, 17:46 authored by Anne Walter, Apirat Chaikuad, Renate Helmer, Nadège Loaëc, Lutz Preu, Ingo Ott, Stefan Knapp, Laurent Meijer, Conrad KunickTG003 (1); NCGC00185963 (2), KH-CB19 (3); benzo[b]thiophen-2-carboxamide 4; T3 (5); TG693 (6); [1,2,3]triazolo[4,5-c]quinoline 7.
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serine-threonine kinasescancer cell linesinhibitor chemotype Cdc 2-like kinasesdocking studiescore scaffoldshow selectivityDYRK kinasesbinding modeMolecular structuresX-ray structure analysesCLK 4CLK proteinsselectivity margincdc 2-like kinasesantiproliferative activitynovel CLK inhibitor familycompound class co-crystallizeddual-specificity tyrosine phosphorylation regulated-kinases
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