pone.0197011.g005.tif (631.71 kB)
CE-SDS electropherograms of anti-BoNT 9ABE under non-reducing and reducing conditions after storage at 5°C (red), 30°C (black) and 50°C (blue) for six months.
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posted on 2018-05-10, 17:35 authored by Mingxiang Li, Dennis Lee, Chidi R. Obi, Joel K. Freeberg, Shauna Farr-Jones, Milan T. TomicA. Non-reducing, stored lyophilized. B. Non-reducing, stored as liquid. C. Reducing, stored lyophilized. D. Reducing, stored as liquid. The peak at approximately 11.5 minutes is an internal standard (STD) of 10 kDa in panels A, C, D.
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powder formulationserotypedrug administrationtoxin domainsbinding capabilitybotulismco-formulated antibodiesorder aggregatesoligoclonal antibody therapiesdrug productbiodefensePhysicochemical characterizationambient temperature-stable antitoxinantibodies obviatesphysicochemical methodsmAbs bindtoxin moleculecharge isoformscleavage productsambient temperature stabilityE Safebinding affinitytoxin-domain binding ELISA databotulinum neurotoxin
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