Binding modes of FMDV integrin receptor and antibody.
figure
posted on 2023-11-20, 18:46 authored by Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin LiuBinding modes of integrin (avβ6) receptor with scFv antibody W2 (A) and W125 (B). The panel shows a view down onto the capsid surface. VP1, VP2, VP3 and VP4 of the protomer are blue, green, red and yellow, respectively. The integrin and antibodies (W2 and W125) are drawn in cartoon representation; integrin is purple; W2 and W125 are respectively colored with orange and cyan. Black dashed circles show significant clashes between antibody (W2 and W125) and integrin receptor.
(TIF)
History
Usage metrics
Categories
Keywords
spectrum molecular vaccinemouth disease viruskey residues locatedbovine sequentially vaccinatedvariable within serotypes19 ), respectivelyvariable antigenic sitesvp3 scattering aroundvp3 175 positionrevealed antigenic variationrelatively stable vp2div >< psea97 lineage ),variable antigen structurestwo bnabs w2conserved antigen structuresvariable vp3sea97 lineagebait antigenw2 concentratedcontact sitesrespectively useddetermined respectivelya22 lineageem structuresvp3 68well resolvedviral particleresistant mutantsg2 genotypeg1 genotypefold axisepitopes recognizeddriven variationsdifferent strainsdesign broadbnab w15339 strain
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC