Bacterial taxa significantly differed by Znt7 genotype in a sex dependent manner.

(A and B) Barplots showing proportions of bacterial taxa present in mouse feces. The microbial community composition of each mouse is represented by a single bar. The proportions of taxa are shown on the y-axis and the cage that each mouse was housed in during the study is shown on the x-axis. Taxa present at less than 2% relative abundance were grouped into the “Other” category. The most specific taxonomic classification obtained is shown and the displayed taxon level is represented by a single letter code preceding the classification; o = order, f = family, g = genus. (C and D) Boxplots of the relative abundance of Allobaculum and Coriobacteriaceae respectively within WT, Znt7^+/- (HET) and Znt7^-/- (KO) mice. A log ratio test, followed by pairwise testing performed in DESeq2 showed a significant sex-specific effect of genotype for these bacterial taxa. *, p<0.05; **, p<0.01.