ArdC structural homologs.

A) Superposition of ArdC (green) with the Rad4 protein bound to UV-damaged DNA (2QSG). The Rad4 TGD domain is shown in beige, BHD1 in pink, BHD2 in purple, and BHD3 in red. For clarity, Rad23 (present in 2QSG structure) has been removed. Detailed view of ArdC ssDBD domain superposed to the Rad4 BHD2 domain. B) Superposition of ArdC (green) with the Spartan SprT domain (6MDX; grey). The SprT Zn2+-binding sub-domain (ZBD) is shown in light grey and the metalloprotease sub-domain (MPD) is shown in dark grey. Detailed view of the metalloprotease active center with the residues involved in catalysis in sticks numbered as (MPD/ArdC). C) Superposition of the ArdC structure (green) with the IrrE-Zn protein from Deinococcus radiodurans (3DTI, grey). Detailed view of the active center with the residues involved in catalysis in sticks numbered as (IrrE/ArdC).