Anxiety-related behaviours in the elevated plus maze (EPM) and the open field test (OF).
figure
posted on 2017-01-12, 18:15 authored by Jac Kee Low, Ananthan Ambikairajah, Kani Shang, David A. Brown, Vicky W. W. Tsai, Samuel N. Breit, Tim Karl(A) Percentage time spent on open arms (excluding centre time) [%], (B) percentage of entries into open arms [%], (C) time spent in the central zone of the OF [s], and (D) ratio of total distance travelled in the central zone of the OF. Data for control (WT) and Mic-1 knockout mice (Mic-1 KO) of both males (M) and females (F) are shown as means + SEM. In the EPM, Mic-1 mice spent more time (p = .002) and also showed more locomotion (p = .01) in the open arms. In the OF, knockout mice spent more time (p < .0001) and showed more locomotion (p < .0001) in the centre.
