ppat.1011811.s005.tif (471.48 kB)
Analysis of conservation of key antigenic determinants on VP1, VP2 and VP3 of FMDV serotype A.
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posted on 2023-11-20, 18:46 authored by Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin LiuThe full amino acids sequences of VP1, VP2 and VP3 of FMDV serotype A were downloaded from national center for biotechnology information (NCBI) as of June 30, 2023. The key antigenic determinants involved in common residues of A/WH/CHA/09, A/GDMM/CHA/2013 and A/AF72 were framed with rectangles and the conservation of corresponding residue was marked with orange. The key residues 58 (Q) and 147 (G, corresponding to RGD+2 position) on VP1 were determined by bnAbs W151, W153 and W145 (A). The key residues VP2 70 (T), 77 (H), 196 (Q) and VP3 61 (K) were targeted by bnAb W125 (B). The key residues 59 (D), 71 (Q), 76 (K), 84 (K) and 132 (T) on VP3 were targeted by bnAb W2 (C).
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spectrum molecular vaccinemouth disease viruskey residues locatedbovine sequentially vaccinatedvariable within serotypes19 ), respectivelyvariable antigenic sitesvp3 scattering aroundvp3 175 positionrevealed antigenic variationrelatively stable vp2div >< psea97 lineage ),variable antigen structurestwo bnabs w2conserved antigen structuresvariable vp3sea97 lineagebait antigenw2 concentratedcontact sitesrespectively useddetermined respectivelya22 lineageem structuresvp3 68well resolvedviral particleresistant mutantsg2 genotypeg1 genotypefold axisepitopes recognizeddriven variationsdifferent strainsdesign broadbnab w15339 strain
